Drug Substance Daptomycin is a novel macrocyclic peptide, with a decanoyl side chain linked to the N-terminus Tryptophan, produced by fermentation of Streptomyces roseosporus.It

The inexorable increase in the prevalence of bacterial resistance since the 1940s now threatens the utility of some antibiotics for treating certain species. Infections due to Gram-positive bacterial species are now the foremost problems in many specialised units and institutions. Methicillin-resistant S. aureus (MRSA), glycopeptide-insusceptible S. aureus (GISA) and glycopeptide-resistant enterococci (VRE or GRE), particularly E. faecium, are of particular concern. For example, the European Antimicrobial Resistance Surveillance System (EARSS) study of 2002 reported that 22% of S. aureus isolates were methicillin-resistant overall, with the highest rates recorded in participating centres in Greece (44%), Ireland (42%), Malta (43%) and the UK (44%). The highest rates of vancomycinresistant E. faecium were reported from Greece (19%), Italy (21%) and Croatia (22%). Bulgaria, Greece and Hungary reported the highest prevalence of high-level aminoglycoside-resistant E. faecalis. Other gram-positive species, such as coagulase-negative staphylococci and Corynebacteria spp., have also caused problems due to acquisition of multiple resistance determinants.